Wake Up Warrior Up Mug. One of the Page lab’s key findings overturned the long-held view that germ-cell sex determination is dependent on the timing of meiotic initiation. Page joined the Whitehead Institute in 1984, as its first Fellow. He joined the Whitehead Institute, as the first Whitehead Fellow, in 1984. The Page lab developed an innovative sequencing approach – SHIMS, or single-haplotype iterative mapping and sequencing – to accurately assemble sex chromosomes, which are the most challenging sequencing targets in their respective genomes. His research twice earned inclusion in Science magazine’s “Top 10 Breakthroughs of the Year,” first for mapping a human chromosome and then for sequencing the human Y chromosome. Members. The 17 Whitehead Institute members include two National Medal of Science winners, nine National Academy of Sciences members, four National Academy of Medicine members, and four Investigators of the Howard Hughes Medical Institute. Lab Website. David C. Page (born 1956) is an American biologist and professor at the Massachusetts Institute of Technology (MIT), the director of the Whitehead Institute, and a Howard Hughes Medical Institute (HHMI) investigator. Whitehead Institute for Biomedical Research, Investigator of the Howard Hughes Medical Institute. Throughout his career, Page has focused on the genetic basis of differences between human males and females, and particularly on the roles of the X and Y chromosomes. Tiny microRNAs help destroy unwanted messenger RNAs in cells. The Page group studies the genetic differences between males and females, both within and beyond the reproductive tract, and the biological and medical ramifications of these differences. Tweets by dwtruthwarrior. Assistant. David Page is interested in the differences and similarities between males and females, in both healthy and disease states. An international search has been launched for Page’s successor. Page was appointed associate director of the institute in 2002, interim director in 2004, and director in 2005. This study yielded insight into the evolutionary dynamics of sex differences in gene expression and revealed how gene expression contributes to an upward shift in the distribution of height or body size in males relative to females. An international search has been launched for […] Our core goal in much of our work is to elucidate sex-biased mechanisms underpinning health and disease. New research finds how the body keeps them in check. The Page laboratory’s long-term effort to sequence the sex chromosomes of eight mammals and chicken has identified genes on the Y chromosome (with counterparts on the X chromosome) that are expressed throughout the body and encode regulators of chromatin modification, transcription, translation, and protein stability. His groundbreaking studies on the Y chromosome changed the way biomedical science views the function of sex chromosomes. Additional mammalian sex chromosome sequencing projects are underway. The lab also found that aberrant crossing-over within the Y chromosome’s palindromes underlies a wide range of disorders of sexual differentiation, including Turner syndrome. Page’s laboratory explores fundamental differences between males and females in health and disease, both within and beyond the reproductive tract. The lab also discovered and characterized an epigenetic mechanism that might explain the unique ability of germ cells to undergo dramatic specialization while retaining the potential to create a new, fully formed organism. The Page group is exploring this hypothesis on several fronts using high-throughput, genome-wide gene expression, proteomic, and epigenetic profiling. The MIT senior will pursue postgraduate studies in global health in Ireland.

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