391 130 10.1038/sj.ki.5001503. This is unusual because amino acid reabsorption by the kidney is highly efficient and generally exceeds 99%. 0000188215 00000 n Such drinks are taken to improve physical performance, although there is little evidence that taurine per se exerts any beneficial effects in healthy individuals or animals without taurine depletion. One patient completed the study with no symptoms or side effects. COVID-19 is an emerging, rapidly evolving situation. Antioxid Redox Signal. 1993, 7 (1): 35-40. Department of Pediatrics, University of Tennessee Health Science Center, and the Children’s Foundation Research Center at Le Bonheur Children’s Medical Center, 50 N. Dunlap, Memphis, Tennessee, 38103, USA, Russell W Chesney, Xiaobin Han & Andrea B Patters, You can also search for this author in 1983, 24 (5): 588-594. Activation of the WT1 (Wilms tumor 1 gene) binding site in the promoter region up-regulates TauT, as does c-Jun. 10.1046/j.1523-1755.2002.00317.x. Adv Exp Med Biol,. In the Masugi glomerulonephritis model, rat kidney homogenates are injected into rabbits. Sodium and chloride move into cells by means of an external to internal downhill Na+ gradient (a chemical gradient), and then the sodium is pumped out of the cell by Na+K+-dependent ATPase. In a gentamicin toxicity model, rats are injected with the aminoglycoside antiobiotic, leading to a rise in serum creatinine and histologic features of acute tubular necrosis. Chesney RW, Friedman AL, Albright PW, Gusowski N: Fasting reverses the renal adaptation to altered dietary sulfur amino acid intake. In a proximal tubule cell line (LLC-PK1), uptake is maximal on the apical surface; in a distal tubule cell line (MDCK), uptake occurs at the basolateral surface (Figure 2) [8]. Receive exclusive offers and updates from Oxford Academic, Copyright © 2020 European Renal Association - European Dialysis and Transplant Association. 2009, 643: 451-461. full_text. showed that taurine in drinking water reduced urinary protein excretion, and both serum and urine platelet-activating factor (PAF) levels [62]. 0000199230 00000 n Last medically reviewed on September 27, 2019, People who eat or are considering vegetarian or vegan diets may be concerned about getting enough protein from their food. Dial. PubMed Google Scholar. Trachtman H, Futterweit S, Bienkowski RS. There occurs a heterologous phase in which injected antibodies lead to the migration of neutrophils into rat glomeruli. Chesney, R.W., Han, X. 10.1203/00006450-198101000-00003. Evidence for hypochlorous acid generation. For example, some studies have shown similar positive benefits in older animals that researchers exposed to toxins. In this article, we look at…. 10.1016/S0895-7061(03)00915-4. Diab Vasc Dis Res. 0000201197 00000 n 0000196370 00000 n Taurine has several beneficial physiological and biochemical effects in vitro and in vivo in experimental animals. 0000190265 00000 n Jpn Circ J. Yes, homeopathy is safe and effective when done by a well-trained, prudent homeopath. 1994;359:31-9 Park T, Rogers QR, Morris JG, Chesney RW: Effect of dietary taurine on renal taurine transport by proximal tubule brush border membrane vesicles in the kitten. CAS  Plasma taurine levels do not vary greatly with the availability of dietary taurine. half the dose that caused excessive accumulation of taurine and neurological symptoms in our patients). 2009, 643: 75-84. full_text. Western blot analysis shows more taurine transporter protein in membranes from LTD-fed animals and less in those fed HTD. Am J Physiol. Am J Clin Nutr. Taurine transport is stereospecific, inhibited by other ß-amino acids and GABA (gamma-aminobutyric acid) but not by α-amino acids, and is membrane surface-specific. 2002, 17 (3): 528-529. No protection in terms of ATP content was found. 1994, 46 (4): 1025-1030. Mol Pharmacol. 0000005503 00000 n Patients with end‐stage renal disease are reported to be taurine depleted with low plasma and muscle intracellular concentrations of taurine [4]. Chesney RW, Scriver CR, Mohyuddin F: Localization of the membrane defect in transepithelial transport of taurine by parallel studies in vivo and in vitro in hypertaurinuric mice. 0000198418 00000 n PubMed Central  0000201057 00000 n 1976, 367 (2): 123-128. 1994, 199 (1): 346-352. The addition of taurine to University of Wisconsin (UW) solution was able to reduce tissue alterations during hypoxia and reoxygenation and permitted recovery of energy metabolism in LLC-PK1 cells [34].

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