; Bartelink, H.; van Leeuwen, F.E. Receiver operating characteristic (ROC) curves were generated, and the area under the ROC curve was calculated to assess the diagnostic accuracy of rPET in detecting a positive response, along with the corresponding cut-off scores. Please enable it to take advantage of the complete set of features! Radiotherapy can also lead to long-term complications, including cardiac and pulmonary toxicity, hypothyroidism, or breast or lung cancers.2432 Radiotherapy can be avoided in patients with stage IA or IIA lymphoma without bulky disease25 (Table 319). Rev. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc. Before Department of Nuclear Medicine and PET-CT, Burjeel Medical City, Abu Dhabi 92510, United Arab Emirates, Academic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, Italy, Amrita Institute of Medical Sciences, Kochi 682041, Kerala, India, Department of Nuclear Medicine, VPS Lakeshore Hospital, Kochi 682040, Kerala, India. This content is owned by the AAFP. How to cite this article: John JR, Oommen R, ; Klokman, W.J. Ann Oncol 2005;16:1514-23. The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. Current NCCN guidelines outline specific monitoring parameters for follow-up and prevention of secondary disease25 (Table 73843). Google Scholar. Shammas, A.; Lim, R.; Charron, M. Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions. 2022 Dec 27;11(1):108. doi: 10.1186/s40164-022-00360-4. Fischman, A.J. SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). The physician should focus on shared decision-making when discussing treatment options with all patients, but particularly for those older than 60 years, including whether the patient should pursue treatment.25, The standard treatment for Hodgkin lymphoma is ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine [Velban], and dacarbazine), but other regimens such as the Stanford V (doxorubicin, vinblastine, mechlorethamine, etoposide [Toposar], vincristine, bleomycin, and prednisone) and escalated-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine [Matulane], and prednisone) can be used.2428 Treatment for non-Hodgkin lymphoma varies depending on the histology, but often uses treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (Rituxan; R-CHOP), a monoclonal antibody specific for CD20-positive B lymphocytes.29 Other medications such as bendamustine (Bendeka), an alkylating agent, and lenalidomide (Revlimid) are also used in many non-Hodgkin lymphoma treatments.30,31 Common complications of these therapies are listed in Table 5.2527,2936. Bookshelf Ann Hematol. An alternative diagnostic method is desirable in both cases, ideally having the same diagnostic performance. Le Roux PY, Gastinne T, Le Gouill S, Nowak E, Bodet-Milin C, Querellou S. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri AJ, Vitolo U. Barnes JA, LaCasce AS, Zukotynski K, Israel D, Feng Y, Neuberg D. Sedig LK, Bailey JJ, Wong KK, Brown RK, Kaminski MS, Hutchinson RJ. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. Purpose: Semin Ultrasound CT MR 2010;31:496-505. was considered. PubMedGoogle Scholar. https://doi.org/10.1182/blood-2018-05-852129 (2018). Ganeshan, B. et al. For this, we considered the readings from S.N.N. Score 3: Uptake > mediastinum but liver. https://doi.org/10.1037//0033-2909.86.2.420 (1979). sharing sensitive information, make sure youre on a federal The volume of the lesion further had to be at least 1 cm3. You seem to have javascript disabled. (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Blood 2008;111:504-16. J.Nucl. Skoetz N, Will A, Monsef I, Brillant C, Engert A, von Tresckow B. Cochrane Database Syst Rev. (ac) A 20-year-old female patient with the initial diagnosis of Hodgkins lymphoma. Milgrom, S. A. et al. Adenopathy can wax and wane over years in indolent presentations or involve rapidly progressive adenopathy in more aggressive subtypes. The study was designed to test if the PET-negative rate after two cycles of BV-AVD was superior to 75%. DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. Disclaimer. Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. Hasenclever, D. et al. Please review the contents of the article and, Barrington et al., Eur J Nucl Med Mol Imaging (2010) 37:18241833. Aide, N.; Lasnon, C.; Veit-Haibach, P.; Sera, T.; Sattler, B.; Boellaard, R. EANM/EARL harmonization strategies in PET quantification: From daily practice to multicentre oncological studies. PubMed 2016 Sep;95(9):1521-35. doi: 10.1007/s00277-016-2736-5. National Library of Medicine Kinahan PE, Fletcher JW. Neither SUV interim nor qualitative assessment of Deauville score has predictive value for HT. Standard of Care is available as a free resource for practicing medical professionals, students and the general public. Expert opinion and clinical review articles, Expert opinion and clinical review article, Non-Hodgkin T-cell and natural killer cell lymphomas, Non-Hodgkin (mucosa-associated lymphoid tissue), Single nodal group or single extralymphatic lesion, Multiple nodal groups on same side of diaphragm or with limited contiguous extralymphatic involvement, Multiple nodal groups on both sides of the diaphragm; may involve the spleen, Serum albumin concentration < 4.0 g per dL (40 g per L), Hemoglobin concentration < 10.5 g per dL (105 g per L), Progressive multifocal leukoencephalopathy, FDG uptake at lymphoma site is mediastinum FDG uptake, FDG uptake at lymphoma site is > mediastinum FDG uptake but < liver FDG uptake, FDG uptake at lymphoma site is > liver FDG uptake at any site, FDG uptake at lymphoma site is substantially > liver FDG uptake or new FDG uptake sites found, Breast: annual screening mammography starting at age 40; history of chest or axilla radiation: start eight to 10 years after treatment or at age 40, whichever comes first; consider annual breast magnetic resonance imaging if chest radiation was received between ages 10 and 30; consider referral to breast subspecialist to discuss possible chemoprevention, Complete blood count, fasting blood glucose, and comprehensive metabolic panel annually, Annual blood pressure screening, lifestyle modification, and treatment of obesity, hypertension, and tobacco use, Age-appropriate immunizations per the Centers for Disease Control and Prevention schedule, including annual influenza vaccine; resume live vaccines at least three months after completion of chemotherapy, Routine surveillance tests for cervical, colorectal, lung, and prostate cancers per the USPSTF guidelines, Consider stress test and/or echocardiography at 10-year intervals (frequency of testing based on findings and other associated risk factors), Neurocognitive impairment screening for any patient who is high risk (e.g., history of brain radiation or intrathecal treatment), PCV13 (Prevnar 13), followed by PPSV23 (Pneumovax 23) at least eight weeks later and again at least five years later, Thyroid-stimulating hormone annually if neck irradiation, Carotid ultrasonography every 10 years if neck irradiation, Infertility: consider reproductive endocrinologist referral. By submitting a comment you agree to abide by our Terms and Community Guidelines. Hodgkin lymphoma (HL) is one of the most common cancer types in young adults with the incidence peaking in people in their 20s. Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. Bookshelf official website and that any information you provide is encrypted We hypothesized a 10% increase in the PET-negative rate after two cycles of BV-AVD. R package version 4.71. This may also be related to a known drawback regarding radiomics, which is their lack of reproducibility, particularly between different scanners16,17,18. EJNMMI Phys 7, 2. https://doi.org/10.1186/s40658-020-0270-y (2020). Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. Epub 2018 Jul 21. J. Nucl. This information was used as the standard of reference for statistical analysis. 21 features overlapped. This cutoff is of the highest relevance7,8. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. ; Kluge, R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. Pretransplant DS/rMTV41% combination and disease status predict the risk of post-transplant treatment failure and will guide risk-stratified approaches in relapsed/refractory cHL. Blautzik, J.; Grelich, L.; Schramm, N.; Henkel, R.; Bartenstein, P.; Pfluger, T. What and how should we measure in paediatric oncology FDG-PET/CT? WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. https://doi.org/10.1038/nrclinonc.2017.141 (2017). Methods: This site needs JavaScript to work properly. Non-Hodgkin lymphoma can originate anywhere in the body, with specific subtypes originating in the gastrointestinal tract, skin, or central nervous system. 2002;359(9323):2065-2071. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. We tested features for inter-reader agreement separately for each scanner by calculating ICCs (ICC3 according to the Shrout and Fleiss Convention31) using the psych package for R32 (Version 2.2.5). Accessibility Radiomic features. 12, 77. https://doi.org/10.1186/1471-2105-12-77 (2011). Flechsig, P. et al. A full list of features with an ICC below 0.8 is given in the supplementary Table S5. Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. and D.K. During clinical follow-up, those patients who had a recurrence/disease progression after completion of therapy were considered non-responders, and the remaining were deemed responders. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. Breast Implant-Associated Anaplastic Large Cell Lymphoma. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. We also searched the Agency for Healthcare Research and Quality evidence reports, UpToDate, the Cochrane database, Essential Evidence Plus, the National Comprehensive Cancer Network, and the Surveillance, Epidemiology, and End Results database. Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkins lymphoma: An analysis from the St Jude Lifetime Cohort Study. The proportion of patients with a Deauville score of 1-3 in the centrally reviewed restaging after treatment with 1 x pembrolizumab + 4 cycles of pembrolizumab and chemotherapy combined (4x P-ICE or 2x P-ICE + 2x P-DHAP) Eligibility Criteria Go to Information from the National Library of Medicine https://doi.org/10.1200/JCO.2013.54.8800 (2014). From these segmentations, 107 features were extracted with PyRadiomics. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. 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As the standard of Care is available as a free resource for practicing medical professionals, students the! J. L. Intraclass correlations: Uses in assessing rater reliability particularly between different scanners16,17,18 national Library of Medicine Kinahan,. Information was used as the standard of Care is available as a free for... Body, with specific subtypes originating in the gastrointestinal tract, skin, or central nervous system paediatric adult.