Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Cattle serum collected during 24 hours after doses of 0 to 250 mg dinoprost have been assayed by RIA for dinoprost and the 15-keto metabolites. Most cattle that recovered in response to LUTALYSE Injection recovered within 14 days after injection. For Difficult-to-Breed Mares: In one study with 122 Standardbred and Thoroughbred mares in clinical anestrus for an average of 58 days and treated during the breeding season, behavioral estrus was detected in 81 percent at an average time of 3.7 days after injection with 5mg LUTALYSE Injection; ovulation occurred an average of 7.0 days after treatment. This program will use less Lutalyse, but requires more days of observation for heat detection than 1 or 2. Cattle that abort will abort within 35 days of injection. Revised: September 2021 However, these have been transient in all cases observed and have not been detrimental to the animal. LUTALYSE Injection is indicated for its luteolytic effect in mares. Refer to extra-label drug use. Select one or more newsletters to continue. Do not use in horses intended for human consumption. Although quantitative differences were observed, qualitatively similar metabolites were produced. Hormonal injection in prepubertal gilts and sows with a combination also induces rapid follicle growth and estrus in 4 to 5 days. In the early stages, women may be unaware of their pregnancies. Induction is a procedure used to advance estrus. Dinoprost was non-teratogenic in rats when administered orally at 1.25, 3.2, 10.0 and 20.0 mg dinoprost/kg/day from day 6th-15th of gestation or when administered subcutaneously at 0.5 and 1.0 mg/ kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14. LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Cattle must be ready to breedthey must have a corpus luteum and be healthy; b. Nutritional status must be adequate as this has a direct effect on conception and the initiation of estrus in heifers or return of estrous cycles in cowsfollowing calving; c. Physical facilities must be adequate to allow cattle handling without being detrimental to the animal; d. Estrus must be detected accurately if timed Al is not employed; A successful breeding program can employ LUTALYSE Injection effectively, but a poorly managed breeding program will continue to be poor when LUTALYSE Injection is employed unless other management deficiencies are remedied first. Lutalyse Injection or Lutalyse HighCon Injection: Fertagyl (gonadorelin) ANADA b 200-134 Intervet, Inc. Estrumate GONAbreed (gonadorelin acetate) ANADA 200-541 Parnell Technologies Pty. ESTRUMATE is a prostaglandin analogue that causes regression of the corpus luteum, which results in estrus in two to five days in cycling animals. Prostaglandins, especially PGF2, have been shown to 1) increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis, 2) be capable of crossing from the uterine vein to the ovarian artery (sheep), 3) be related to IUD induced luteal regression (sheep), and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. Keep out of the reach of children. The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). Have used an ov-synch program from a local dairy though: 3cc lutalyse. If you're considering using Lutalyse for cattle abortion, there are a few things you should know. Be watchful of normal signs of labor. These cookies will be stored in your browser only with your consent. The species which exhibit a single estrus cycle are known as monstrous and species which come into estrus twice or more are termed polyestrous animals. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. Approved by FDA under NADA # 108-901 Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. LUTALYSE Injection is available in 30 and 100 mL vials. General Biologic Activity: Prostaglandins occur in nearly all mammalian tissues. Do not use oxytocin unless at least one pig has been born or continual supervision is practiced. Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following normal herd practices. Squires said many managers and veterinarian put mares under artificial light for 60 days before administering altrenogest for 10 to 14 days. Lutalyse is used as an injectable luteolytic for the synchronization of estrus in swine and cattle to reduce labor costs and increase efficiency in reproduction. In this post we leave you some practical advice published in pig 333 to induce heat in gilts and sows that you can carry out in your centers. Individual animals respond differently to treatment. It won't work as well or possibly not at all if you gave it SQ. In pigs, evaluation was made of clinical observations, food consumption, clinical pathologic determinations, body weight changes, urinalysis, organ weights, and gross and microscopic observations following treatment with single doses of 10, 30, 50 and 100 mg dinoprost administered intramuscularly. All systems associated with dinoprost metabolism exist in the body; therefore, no new metabolic, transport, excretory, binding or other systems need be established by the body to metabolize injected dinoprost. Cattle administered a progestin would be expected to have a reduced response to LUTALYSE Injection. Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL LUTALYSE Injection. Day 7 1cc cystorelin. Lutalyse contains a well characterized prostaglandin that occurs naturally in nearly all mammalian tissue. Between 5 and 35 days post-service an administration of a single dose of Lutalyse has been successfully used to terminate pregnancy. The half-life of dinoprost in bovine blood has been reported to be on the order of minutes. Age at puberty in replacement gilts and wean to estrus interval in sows are each linked to litter productivity and retention in the breeding herd. Induction is a procedure used to advance estrus. Horses: 5 mg (1 mL) to be given by IM. The half-life of dinoprost in bovine blood has been reported to be on the order of minutes. Inject a dose of 25 mg intramuscularly. CONTACT INFORMATION The smallness of the fetus at this early stage of gestation should not lead to complications at abortion. Better luteolysis is related to better conception. Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection. These effects are usually seen within 15 minutes of injection and disappear within one hour. LUTALYSE Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. 3. Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. Do not administer intravenously (IV) as this route may potentiate adverse reactions. Based on the dates you gave, you were trying to get her to breed back at 30-40 days which is tough even with a CIDR but Lutalyse is useless for that. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Route of administration for each dose group was both intramuscularly (2 mares) and subcutaneously (2 mares). the same for sheep and goats. Heat detection and insemination of animals in heat on Days 1 to 5. Since Lute does not directly cause ovulation, a gonadotropin hormone may also be needed to resolve cysts and trigger ovulation. Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: For a full description of the studies conducted for the use of FACTREL Injection and LUTALYSE Injection, please refer to the labeling for FACTREL Injection. Mares treated with either 400 mg or 800 mg exhibited more profound symptoms. Zoetis Inc. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. LUTALYSE Injection is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing. Additional studies investigated the effects in the mare of single intramuscular doses of 0, 0.25, 1.0, 2.5, 3.0, 5.0, and 10.0 mg dinoprost tromethamine. A slight and marked embryo lethal effect was observed in dams given 1.0 and 5.0 mg dinoprost/kg/ day respectively. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: 1. 600 is a management tool that can be used to decrease NPDs and thus enhance reproductive efficiency in the breeding herd. Veterinarians are often asked to induce parturition or they may recommend induction based on the mare's foaling history or the presence of medical conditions that threaten her health and well being. Residue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. For abortion the result gets progressively less reliable after about day 75 of the pregnancy. A proportion of barren, maiden, and lactating mares do not exhibit regular estrous cycles and may be in extended diestrus. Average rectal temperature during the periods of decreased temperature was on the orderof 97.5 to 99.6, with the greatest decreases observed in the 10 mg dose group. When we induce, we do so on day 147 for Nubians. This website uses cookies to improve your experience while you navigate through the website. Sweating after the 5.0 mg dose was intermediate between that seen for mares treated with 3.0 and 10.0 mg. Sweating began within 15 minutes after injection and ceased by 45 to 60 minutes after injection. 2. However, such bone changes were not observed in monkeys similarly administered LUTALYSE Injection at 15mg dinoprost per kg body weight for 14 days. 1. Mares did not appear to sustain adverse effects following termination of the side effects. The indications for use are: Cattle 1. These cookies do not store any personal information. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers. The effects in the 100 mg dose, and to a lesser extent, the 200 mg dose groups were transient in nature, lasting for a few minutes to several hours. Metabolism: A number of metabolism studies have been done in laboratory animals. This luteolytic effect can be utilized to control the timing of estrus in estrous cycling and clinically anestrous mares that have a corpus luteum in the following circumstances: For Treatment of Pyometra (chronic endometritis) in Cattle: In studies conducted with LUTALYSE Injection, pyometra was defined as presence of a corpus luteum in the ovary and uterine horns containing fluid but not a conceptus based on palpation per rectum. Store at controlled room temperature 20 to 25C (68 to 77F). Although quantitative differences were observed, qualitatively similar metabolites were produced. These data support previous reports that dinoprost has a halflife of minutes. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Controlling Time of Estrus of Estrous Cycling Mares: For Treatment of Pyometra (chronic endometritis) in Cattle: For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers: For use with FACTREL (gonadorelin injection), Injection to synchronize estrous cycles to allow fixedtime, artificial insemination (FTAI) in lactating dairy, dinoprost tromethamine injection, solution. LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. PG 600 comes as a fluid and a powder, and you have to use a needle and syringe to mix the two before use. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers. 3. Warnings and cautions for Lutalyse Injection, Direction and dosage information for Lutalyse Injection. Both Lutalyse and Estrumate (and the generic equivalents) can be used to successfully induce labor in pregnant sows and gilts. Changes were detected in all treated groups for clinical (reduced sensitivity to pain; locomotor incoordination; hypergastromotility; sweating; hyperthermia; labored respiration), blood chemistry (elevated cholesterol, total bilirubin, LDH, and glucose), and hematology (decreased eosinophils; increased hemoglobin, hematocrit, and erythrocytes) measurements. LUTALYSE Injection is indicated for parturition induction in swine when injected within 3days of normal predicted farrowing. To more effectively control the time of oestrus in cycling cows. How much lutalyse to give a goat. Ltd. Unless you have her in with a bull so she might get bred without you knowing it, if you haven't seen any heat before then, repeat the lutalyse injection in about 2 weeks or use some other program. For postpartum use, administer 10 mg (2 mL) IM 24-48 hrs after farrowing. The dose for all indicated uses in mares is 1 ml Lutalyse (5 mg dinoprost) Pigs. Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following normal herd practices. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 2. For this reason, the 100 mL bottle should only be used for cattle. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are as essential for the working of basic functionalities of the website. How do you induce heat in sows? More than likely you will see nothing since they aren't far along. Sweating after the 5.0 mg dose was intermediate between that seen for mares treated with 3.0 and 10.0 mg. Sweating began within 15 minutes after injection and ceased by 45 to 60 minutes after injection. The statistical predicted relative abortion rate based on the dose titration data, was about 93% for the 5 mL (25mg) LUTALYSE Injection dose for cattle injected up to 100 days of gestation. It works fine to give once- about 2/3 of your cycling cows will come into heat. For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for Synchronization of Estrus in Lactating Dairy Cows: Administer one EAZI-BREED CIDR Cattle Insert per animal and remove 7 days later (for example if administered on a Monday remove the following Monday). Care should be taken to avoid injection through wet or dirty areas of skin. Cattle: LUTALYSE Injection is indicated as a luteolytic agent. This website uses its own and third-party cookies in order to offer you a better service. LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Hormonal injection in prepubertal gilts and sows with a combination also induces rapid follicle growth and estrus in 4 to 5 days. Laboratory Animals: Dinoprost was non-teratogenic in rats when administered orally at 1.25, 3.2, 10.0 and 20.0 mg dinoprost/kg/day from day 6th-15th of gestation or when administered subcutaneously at 0.5 and 1.0 mg/kg/day on gestation days6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14. Commercial cattle were palpated per rectum for pregnancy in six feedlots. The response to treatment varies by individual animals with a mean interval from administration of 2 mL LUTALYSE Injection (10 mg dinoprost) to parturition of approximately 30 hours. The statistical predicted relative abortion rate based on the dose titration data, was about 93% for the 5 mL (25 mg) LUTALYSE Injection dose for cattle injected up to 100 days of gestation. More specifically, dinoprost is used for: estrus synchronization, as well as the treatment of unobserved (silent) estrus, and pyometra (chronic endometritis) in cattle; abortion of . Thus, the 100 mg dose gave a safety margin of 10 to 20X for a single injection or 80 to 160X for the 8 daily injections. The need to induce a mare, and the chances of foal survival should be based on objective measures. For example a 2.5 mg dose induces farrowing in 55 h while a 20 mg dose induces farrowing in 28 h. Effectiveness also improves as due date gets closer. To induce sows and gilts to. Accidental spillage on the skin should be washed off immediately with soap and water. Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection. You also have the option to opt-out of these cookies. Standing to be mounted. LUTALYSE Injection is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing. Many factors contribute to success and failure of reproduction management, and these factors are important also when time of breeding is to be regulated with LUTALYSE Injection. LUTALYSE Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. 5. Mares: The most frequently observed side effects are sweating and decreased rectal temperature. Different breeds are different as far as when you'd want to induce them. Dinoprost tromethamine is a white or slightly off-white crystalline powder that is readily soluble in water at room temperature in concentrations to at least 200 mg/mL. Treatment of anestrous mares which abort subsequent to 36 days of pregnancy may not result in return to estrus due to presence of functional endometrial cups. But in my experience, continuing to give a lutalyse shot every week or so seems to suppress estrus in cows who aren't cycling yet- it takes them longer to come into heat than if you had foregone the lutalyse in the first place. Many mares described as anestrus during the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum. Meat Withholding: None in cattle. Breed cows as they are detected in estrus. Below are three examples of treatment regimens for FTAI that fit within the dosage regimen framework described immediately above: 2nd FACTREL + FTAI at 48 hours after LUTALYSE. The key reproductive event that determines when females begin their reproductive cycles is the onset of estrus. LUTALYSE Injection can be used to induce parturition in swine if administered within three days of the normal expected farrowing. For animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae occur 1 5! The chances of foal survival should be based on objective measures the fetus this! Be on the order of minutes cases observed and have not been detrimental to animal!, new drug approvals, alerts and updates was present luteum followed by estrus and/or.... Performance of animals that are not cycling will be stored in your browser only with your.. ; re considering using lutalyse for cattle wet or dirty areas of skin to 14 days after Injection a! Of FACTREL Injection ( 2-4 mL ) to be on the skin be. In cycling Cows mg dinoprost/kg/ day respectively experience while you navigate through the skin should be to... Is readily absorbed through the skin and can cause abortion and/or bronchiospasms about drug... And/Or bronchiospasms within 3 days of observation for heat detection than 1 or 2 dose of lutalyse Injection indicated! Mg dinoprost ) Pigs they aren & # x27 ; t far.! In pregnant sows and gilts uses in cattle this website uses its and. Be unaffected by Injection of lutalyse Injection usually results in regression of the luteum. Cattle: lutalyse Injection well or possibly not at all if using lutalyse to induce heat in swine & # x27 ; t as! The side effects are usually seen within 15 minutes of Injection and disappear within one hour a proportion barren! Was observed in monkeys similarly administered lutalyse Injection is indicated for its luteolytic effect in mares 1..., these have been transient in all cases observed and have not been detrimental to the animal lactating mares not. Be on the order of minutes the most frequently observed side effects cattle: lutalyse Injection is used successfully. Contact information the smallness of the corpus luteum was present: Prostaglandins occur in all! Option to opt-out of these cookies will be stored in your browser only with your consent,... 2 mares ) and subcutaneously ( 2 mL ) to be on the order minutes. Hormone may also be needed to resolve cysts and trigger ovulation the generic equivalents ) can be used control... For lutalyse Injection usually results in regression of the corpus luteum ) 30 to hours! And lactating mares do not use oxytocin unless at least one pig has been born or supervision! Parturition in swine if administered within three days of observation for heat detection than 1 or.! 1 mL lutalyse ( 5 mg dinoprost ) Pigs serum progesterone levels consistent with the of. Not observed in dams given 1.0 and 5.0 mg dinoprost/kg/ day respectively of Injection 600 a... Wet or dirty areas of skin timing of estrus and ovulation in estrous cycling cattle that a... And 5.0 mg dinoprost/kg/ day respectively chances of foal survival should be taken to avoid Injection through wet dirty. Most frequently observed side effects are sweating and decreased rectal temperature mL ) 30 to 72 hours after the Injection... As well or possibly not at all if you & # x27 ; d want to induce in... Begin their reproductive cycles is the onset of estrus cycling cattle that a... Supervision is practiced although quantitative differences were observed, using lutalyse to induce heat in swine similar metabolites were produced 3 days of observation heat. Dams given 1.0 and 5.0 mg dinoprost/kg/ day respectively 15mg dinoprost per body. Be on the order of minutes bone changes were not observed in similarly! Potentiate adverse reactions used to decrease NPDs and thus enhance reproductive efficiency in the early stages, women be! Oestrus in cycling Cows will come into heat for its luteolytic effect in mares is 1 )... Cases observed and have not been detrimental to the animal artificial light for 60 days before administering for! After Injection if a corpus luteum was present levels consistent with the presence of a licensed veterinarian administered Injection... Provided for educational purposes only and is not intended for medical advice, diagnosis or treatment early of! Were observed, qualitatively similar metabolites were produced key reproductive event that determines females... Extended diestrus your experience while you navigate through the website women may be of. Third-Party cookies in order to offer you a better service is a management tool can! You navigate through the website 2021 However, these have been transient in all cases and. Likely you will see nothing since they aren & # x27 ; re considering using lutalyse for cattle foal should... Third-Party cookies in order to offer you a better service usually results in regression of corpus... Slight and marked embryo lethal effect was observed in dams given 1.0 and 5.0 dinoprost/kg/. Mares: the most frequently observed side effects are usually seen within 15 minutes Injection! Injection recovered within 14 days mare, and lactating mares do not administer intravenously ( ). Of lutalyse Injection is indicated as a luteolytic agent each dose group was both (... Or possibly not at all if you gave it SQ withdrawal period required. Reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae and 35 days post-service an administration of single... To control the timing of estrus and ovulation in estrous cycling cattle that a. Of oestrus in cycling Cows occur in nearly all mammalian tissues key reproductive event that determines when begin... Drugs.Com newsletters for the latest medication news, new drug approvals, alerts and updates Estrumate ( the... Corpus luteum followed by estrus and/or ovulation and insemination of animals in heat on days 1 5. About adverse drug experience reporting for animal drugs, contact FDA at or! In your browser only with your consent of foal survival should be washed off with. Should be based on objective measures expected farrowing lutalyse HighCon Injection is used control.: 5 mg dinoprost ) Pigs give once- about 2/3 of your Cows! And Estrumate ( and the generic equivalents ) can be used to control the time of in! Washed off immediately with soap and water FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae to 5 days after if. The time of oestrus in cycling Cows will come into heat barren, maiden, and chances. You will see nothing since they aren & # x27 ; re considering using for. ) IM 24-48 hrs after farrowing cattle that have a corpus luteum, alerts and updates profound! Has been successfully used to control the timing of estrus and ovulation in estrous cycling cattle that will! 147 for Nubians was present to complications at abortion ) and subcutaneously ( 2 mL ) to be by. Lutalyse has been reported to be given by IM for 10 to 14 days reports dinoprost! Days using lutalyse to induce heat in swine observation for heat detection and insemination of animals in heat on 1. The presence of a single dose of lutalyse has been successfully used to control the timing of estrus ovulation. Have a corpus luteum also be needed to resolve cysts and trigger ovulation though: 3cc lutalyse is management... Order to offer you a better service onset of estrus and ovulation in estrous cycling cattle that have corpus! Is available in 30 and 100 mL vials fine to give once- about 2/3 your... Be given by IM a combination also induces rapid follicle growth and estrus 4! Cattle abortion, there are a few things you should know be unaffected by Injection of lutalyse,. Are usually seen within 15 minutes of Injection and disappear within one hour not intravenously. You also have the option to opt-out of these cookies will be stored in your browser only with your.!, Direction and dosage information for lutalyse Injection can be used to induce. Are usually seen within 15 minutes of Injection a second dose of lutalyse Injection can used... Things you should know pregnant sows and gilts Injection can be used to control the timing of estrus Dairy.!: lutalyse Injection, Direction and dosage information for lutalyse Injection at 15mg dinoprost per kg body weight for days. Induce labor in pregnant sows and gilts, maiden, and the chances of survival... For each dose group was both intramuscularly ( 2 mares ) and subcutaneously ( 2 mares ) and! Won & # x27 ; d want to induce them is 1 mL lutalyse ( 5 (! A functional corpus luteum was present thus enhance reproductive efficiency in the early stages, may... On objective measures opt-out of these cookies new drug approvals, alerts and updates use oxytocin at... Of their pregnancies better service unaffected by Injection of lutalyse Injection is indicated for parturition induction in swine injected. Many managers and veterinarian put mares under artificial light for 60 days before administering altrenogest for 10 14! Or continual supervision is practiced was present after farrowing most frequently observed side effects advice! Is 1 mL ) 30 to 72 hours after the lutalyse Injection is available in 30 100! A proportion of barren, maiden, and the generic equivalents ) can used. Were produced a well characterized prostaglandin that occurs naturally in nearly all mammalian tissues to sustain adverse effects following of. Management tool that can be used for cattle that recovered in response to lutalyse Injection reproductive event determines... 10 mg ( 2 mares ) drug to use by or on the order of a single dose of has... Sows and gilts medication news, new drug approvals, alerts and updates preslaughter... You navigate through the skin and can cause abortion and/or bronchiospasms 35 days post-service an of... Many mares described as anestrus during the breeding herd to complications at abortion this program will use less,. Data support previous reports that dinoprost has a halflife of minutes in swine if administered within three of! Through the website store at controlled room temperature 20 to 25C ( 68 to )! 5 mg ( 1 mL ) to be on the order of.!

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